It was found that heat treatment of 1, 5-bis(5-nitro-2-furyl)-3-pentadienone guanylhydrazone hydrochloride converted it into a compound which showed marked antibacterial action against gram-positive and -negative bacteria. Therefore, this original compound was treated in butanol at 130° for 2 hours and the residue obtained by evaporation of butanol afforded two kinds of products, named A and C, with different chemical and antibacterial behavior. Product A showed bactericidal effect against dysentery bacilli in a dilute solution of 0.1γ/cc. and this action was found to be 1000 times greater than that of the parent hydrochloride.
