1962 年 82 巻 1 号 p. 75-81
Seventeen kinds of new antipyrine derivatives were synthesized, including those possessing an amidoxime group (IV-X), imidazo[1, 2-a]pyridine ring (XI-XIV), and 3-(4-antipyrinyl)pyrazole (XV), 5-(4-antipyrinyl)-2-methylthio-1, 3, 4-thiadiazole (XVIII), 4-3-(chloropropionyl)antipyrine (XIX), 4-acrylantipyrine (XX), 4-(3-chloropropionamido)antipyrine (XXI), and 4-(5-nitrofurfurylideneamino)antipyrine (XXII). These compounds, and the known antipyric acid hydrazide and formylantipyrine oxime for comparison, were tested in vitro against human-type tubercle bacilli, Staph. aureus, and E. coli. Growth inhibition against tubercle bacilli, though weak, was found in the compounds with amidoxime (IV-VIII) and (XXII), but not in others, while only (XXII) was effective in inhibiting the growth of Staph. aureus, also to a weak degree. None of the compounds were effective against E. coli.