放線菌抗生物質の化学的研究 (第11報)
Racemomycin その8 Racemomycin A, B, Cについて
1962 年 82 巻 1 号 p. 87-91
詳細
1962 年 82 巻 1 号 p. 87-91
Separation and purification of Racemomycin complex, produced by a mutant strain of Streptomyces recemochromogenus SUGAI, SHINOBU et OTANI, was reported earlier but reëxaminations were made on some insufficient points. It was found that the sulfates of Racemomycin A, B, and C can be separated and purified by column chromatography using cellulose powder. Racemomycin A, B, and C have β-lysine and reseonine as the constituent component of their molecule and are assumed to be chemically similar antibiotics but they show difference in their biological activity. It was assumed that Racemomycin-A is an antibiotic with strong antibacterial activity and without acute toxicity or delayed toxicity. All racemomycins A, B, and C are labile to acid and alkalis, and require great care in their preservation.
