YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
フラン誘導体の化学的ならびに実験化学療法的研究 (第28報)
3-Amino-6-〔2-(5-nitro-2-furyl)vinyl〕-as-triazineの諸種アルキル誘導体の合成ならびに抗菌性について
三浦 孝次池田 政男大橋 冨次市村 圭子五十嵐 良子
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1962 年 82 巻 11 号 p. 1464-1467

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Decomposition of 1, 5-bis(5-nitro-2-furyl)-3-pentadienone N4-alkylamidinohydrazone by heating in organic solvent, in the presence of a basic catalyst, resulted in the formation of a 1, 2, 4-triazine ring inside the molecule and a series of new compounds, 3-alkylamino-6-[2-(5-nitro-2-furyl)vinyl]-as-triazines, were obtained. These triazine derivatives had a wide antibacterial spectrum and were found to inhibit the growth of gram-negative bacteria (dysentery, typhoid, and coli bacilli) in a dilute solution of 10, 000, 000 to 40, 000, 000 dilutions. Moreover, these derivatives were found to have very low toxicity and their oral administration resulted in good absorption, with excretion of urine retaining marked antibacterial activity.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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