1962 年 82 巻 11 号 p. 1476-1479
Chloramphenicol is rapidly absorbed and attempts were made to prolong the duration of its action by controlling this absorption. Chloramphenicol was made into granules using a binder which would undergo disintegration in digestive tract and liberate chloramphenicol gradually, and this rate of dissolution was examined. Several kinds of granules showing different dissolution curve were selected and these were administered orally to rabbits to measure the blood level of chloramphenicol. It was thereby found that the blood level of chloramphenicol is low at the beginning but clearly showed longer duration and the dissolution curve in vitro was found to give a suggestion of duration of granules. In order to increase the initial concentration of granules, chloramphenicol crystal was administered orally at the same time and this was found to give a constant blood level for 10hours after the administration.