YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
シダ類の薬学的知見 (第17報)
ヌリワラビの成分について その2
上野 明
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ジャーナル フリー

1962 年 82 巻 11 号 p. 1486-1488

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The structures of both athyriol and isoathyriol have been investigated.
Phloroglucinol and 2, 4, 5-trihydroxybenzoic acid was condensed, in a presence of zinc chloride and phosphorus oxychloride to norathyriol through a novel reaction applying the Grover method. Following the same route of reaction, 1, 3, 6-trihydroxy-7-methoxyxanthone (II) from 2, 4-dihydroxy-5-methoxybenzoic acid, as well as 1, 3, 7-trihydroxy-6-methoxyxanthone (III) from 2, 5-dihydroxy-4-methoxybenzoic acid were synthesized.
Isoathyriol was identical with (III) and its triacetate was also identical with 1, 3, 7-triacetoxy-6-methoxyxanthone, therefore the structure of athyriol has been determined to be (III). As to the athyriol, it was identical neither with (II) nor (III) and the color reaction suggested a presence of free ortho-diphenolic structure, therefore, 1, 6, 7-Trihydroxy-3-methoxyxanthone has been determined as a structure of athyriol.

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