YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Sinomenineの還元成績体に関する研究 (第3報)
DihydrothebainolのC6位水酸基の配位の考察
岡部 啓
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ジャーナル フリー

1962 年 82 巻 11 号 p. 1503-1507

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Dihydrothebainol-A methyl ether (XVI) is far more easily acetylated than dihydrothebainol-B methyl ether (XVIII). Catalytic reduction of dihydrothebainone 4-acetate (XXII) in glacial acetic acid over platinic oxide resulted in formation of dihydrothebainol-B 6-acetate (XXIV), besides dihydrothebainol-B 4-acetate (XXIII) which easily underwent acyl migration during alumina chromatography to transit to the 6-acetate (XXIV). These experimental evidences suggest that the hydroxyl group at 6-position of dihydrothebainol-B (XV) takes a configuration close to the hydroxyl at 4-position, i.e. axial configuration.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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