1962 年 82 巻 11 号 p. 1547-1552
In order to examine an influence upon blood sugar by cyclization of chained urea structure of the sulfonylurea compounds which possess descending action of blood sugar, the following compounds were prepared. These compounds synthesized were: 1-arylsulfonyl-2-imidazolidinone (XI), 1-arylsulfonyltetrahydro-2(1H)-pyrimidinone (IX), 1-arylsulfonyl-2-imidazolidinethione (XV), 1-aroyl-2-imidazolidinone (XIII) and N-p-chlorophenylsulfonyl derivatives of 2-iminoöxazolidine, 2-oxazolidinone, 2-pyrrolidinone, ethylenediamine and pyrrolidine.
When 1-arylsulfonyl-3-(3-bromopropyl) urea (VII) was treated by alkali, it was cyclized easily to (IX) and, simultaneously, 2-arylsulfonamido-5, 6-dihydro-4H-1, 3-oxazine (VIII) was obtained.