1962 年 82 巻 11 号 p. 1553-1557
The influence of 40 kinds of 1-arylsulfonyl-2-imidazolidinone and its related compounds, whose cyclic ureide structure were converted from the straight-chained urea structure of sulfonyl urea derivatives, having blood-sugar descending action upon normal rabbit has been studied by oral administration. Some of 1-arylsulfonyl-2-imidazolidinone and 1-arylsulfonyltetrahydro-2(1H)-pyrimidinone were found to indicate such a strong blood-sugar ascending action of having max. 300mg%. The details of 1-(p-chlorophenylsulfonyl)-2-imidazolidinone which showed the strongest action among them were examined and it was clarified that the administration of 200mg./kg. showed two ascending peaks of blood-sugar action within 48 hours and that this high blood-sugar action antagonized completely with Tolbutamide. The correlation between the structure and the action was considered and an indispensable structure for blood-sugar ascending action was suggested to be . Furthermore, the similarity of the relationship between these series of compounds and sulfonyl urea compounds having blood-sugar descending action was also interpreted by the relationship between the structure and the action.