YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
フラン誘導体の化学的ならびに実験化学療法的研究 (第29報)
3-Amino-6-〔2-(5-nitro-2-furyl)vinyl〕-as-triazineのC-alkyl誘導体について
市村 圭子
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ジャーナル フリー

1962 年 82 巻 11 号 p. 1558-1560

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Condensation of methyl ethyl ketone and 5-nitro-2-furfural diacetate afforded 1, 5-bis(5-nitro-2-furyl)-2-methyl-3-pentadienone (I) and 3-methyl-4-(5-nitro-2-furyl)-3-buten-2-one (II). By the reaction of these compounds with aminoguanidine, their amidinohydrazone hydrochlorides were purified. Heating of the amidinohydrazone of (I) in organic solvent, in the presence of alkaline substance, gave 3-amino-6-[1-methyl-2-(5-nitro-2-furyl)vinyl]-as-triazine. Antibacterial activity of these compounds was examined and interesting results were obtained.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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