ホモスルファミンの定量法ならびに分解に関する研究 (第5報)
ホモスルファミンの尿中濃度測定法ならびにその排泄
1962 年 82 巻 12 号 p. 1582-1587
詳細
1962 年 82 巻 12 号 p. 1582-1587
The biological metabolites of homosulfanilamide were found to be p-carboxy-benzenesulfanilamide and acetamidomethylbenzenesulf anilamide. Examinations were made on the determination in urine to measure unchanged homosulfanilamide alone and this was found to be possible by a slight modification of the method reported earlier for the measurement of its blood level. The separatory determination of the metabolites was effected by the use of paper chromatography. Homosulfanilamide was administered to men and the value of the metabolites excreted was determined. p-Carboxybenzenesulfanilamide was found to be excreted in the largest amount and a part of it was excreted as p-acetamidomethylbenzenesulfanilamide, together with the unchanged homosulfanilamide.
Experiments with rabbits showed that combined use of β-phenylisopropylhydrazine of comparatively small toxicity or isonicotinic acid hydrazide resulted in decreased excretion of p-carboxybenzenesulfanilamide compared to the single administration of homosulfanilamide and the amount of unchanged homosulfanilamide was found to be 2-6 times higher than that in single administration.
