ホモスルファミンの定量法ならびに分解に関する研究 (第6報)

消化器管ならびに肝臓におけるホモスルファミンの分解

抄録

Homosulfanilamide was found to be decomposed in the body and, in order to examine the location of this decomposition, mode of its decomposition in the digestive tract and various organs was examined.
Decomposition in the digestive tract was examined by the use of simulated gastric juice, intestinal juice, and enteric bacteria (Escherichia coli communior, Streptococcus faecalis R, and Lactobacillus acidophilus) but there was no evidence of decomposition and a marked decomposition was found to be effected by intestinal mucosa enzyme.
Further examination using the homogenate of rabbit liver and by the perfusion test with excised rabbit liver showed a marked decomposition to take place in both cases. Decomposition of homosulfanilamide on addition of β-phenylisopropylhydrazine or isonicotinic acid hydrazide was examined and it was found that the decomposition of homosulfanilamide was only 30-40% on addition while that of homosulfanilamide was 70% after about 5hours. However, in the test with intestinal mucosa enzyme, effect of these inhibitors was not observed.