3-Acetyl-4-hydroxycoumarinおよびDehydroacetic Acidの抗菌作用機作 (第2報)
1962 年 82 巻 12 号 p. 1631-1634
詳細
1962 年 82 巻 12 号 p. 1631-1634
The inhibitory effect of 3-actyl-4-hydroxycoumarin (AHC) and dehydroacetic acid (DHA) on the biosyntheses of nucleic acids and proteins, as well as on the fermentation or the respiration of lactobacillus and yeast was examined. At a concentration of AHC or DHA where the syntheses of nucleic acids and proteins were markedly inhibited, the fermentation of lactic acid by L. arabinosus was rather promoted (about 7%). The inhibition of respiration of Sacch. cerevisiae was found much less than that of the synthesis of nucleic acids and proteins. These effects of AHC or DHA were similar to those reported for 2, 4-dinitrophenol as a growth inhibitor. Accordingly, it is probable that the inhibitory activity of AHC or DHA against these microörganisms depends on an uncoupling of the reactions concerned with anabolic and catabolic metabolism, e.g. oxidative phosphorylation.
