1-フェニル-2-チオバルビツール酸誘導体の合成とその鎮痛作用
1962 年 82 巻 7 号 p. 976-980
詳細
1962 年 82 巻 7 号 p. 976-980
5-Alkylamino-2-thiobarbituric acid derivatives containing a p-substituted phenyl group in the nitrogen were synthesized in order to examine the presence of analgesic action in a compound by the introduction of two kinds of atom group, one having a pyrolytic and the other hypnotic activity, in one molecule. Attempt for further introduction of an alkyl group in the carbon atom at 5-position failed. Pharmacological test of 19 kinds of the barbituric acid derivatives synthesized showed that none of them had a strong analgesic action.
