コデインNオキシドの生体内変化
1962 年 82 巻 8 号 p. 1109-1114
詳細
1962 年 82 巻 8 号 p. 1109-1114
Metabolism of codeine N-oxide (I) was examined using an albino rat. Codeine (II′) and norcodeine (IV′) were identified as the metabolic products by paper chromatography and an unidentified spot (V′), whose Rf value agreed with that of acetylcodeine (V), was also detected. Further, codeine (II′) was extracted from the urine as the metabolite, isolated as colorless prismatic crystals, and confirmed by its derivation to the picrate and acetate. The amount of metabolites excreted after administration of (I) by various methods, and the blood level and excretion into bile after intravenous injection were determined. Liver perfusion test revealed the formation of codeine. Finally, some considerations were made on the relationship between the metabolism of codeine N-oxide and its pharmacological activity.
