フェノキサゾン化合物の生体物理化学的研究 (第1報)

拡散定数および会合度について

抄録

In order to investigate the behavior of phenoxazine compounds in living body from the standpoint of biophysical chemistry, the measurements of diffusion constants, as well as the degree of association are described in this report with 4 kinds of phenoxazine compounds such as xanthommatin, extracted from eyes of Musca domestica and the synthesized pigments, such as catalin, A-catalin and C-catalin. The value of the diffusion constants increased as the temperature rose and, under the same condition of temperature, the value was inclined to be smaller, as the molecular weight become larger. The value of A-cataline was observed to be smaller than that was expected from the molecular weight. The degree of association calculated from the diffusion constant of each pigment at the respective temperature showed that catalin was not almost associated at 37°, but the other pigments associated into 2 to 3 molecules, at the same time the degree of association increased as the temperature became lower. With A-catalin and xanthommatin, this phenomenon was remarkable and the degree of association of C-catalin has undergo any influence by temperature.