Synthesis of 1′, 2′-Dihydrospiro[cyclohexane-1, 4′(3′H)-isoquinoline]-6′-ol Derivatives by the Bischler-Napieralski Reaction

Abstract

2′-Methyl-1′, 2′-dihydrospiro[cyclohexane-1, 4′(3′H)-isoquinolin]-6′-ol (VI) derivatives was synthesized by cyclization of 1-(m-methoxyphenyl)cyclohexanemethylamine (II) by the Bischler-Napieralski and Pictet-Spengler reactions. The Bischler-Napieralski reaction of II derivative not possessing a methoxy group afforded 1′, 2′-dihydrospiro[cyclohexane-1, 4′(3′H)-isoquinolin] (XIV) derivative.