YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
水溶性, 結晶性薬剤の湿潤性に関する研究 (第5報)
黒田 耕司
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ジャーナル フリー

1963 年 83 巻 4 号 p. 337-342

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The relationship between the absorption amount of moisture, W, and relative humidity, H, of both water-soluble mixture and crystalline solid was shown by linearity, at the beginning of moistening, and it was found that equation (1) was roughly established experimentally. Therefore, critical relative humidity (CRH), calculated by the pre-equlibrium method, was found to be an approximate value to the humidity when the hygroscopic velocity becomes zero. A selection of relative humidity, H, and time, t, in order to obtain CRH with high accuracy, was examined.
K of equation (1) is a constant stipulated only by the kind and temperature of the component in the mixture but it was found to be influenced slightly by the composition and inhomogenuity of the mixture. If the component of the mixture is biassed to one side, or if it is extremely inhomogeneous, the accuracy of CRH become poor.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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