1963 年 83 巻 5 号 p. 480-487
In the previous report, the synthesis of N-substituted amino acid amide derivatives, a remarkable pharmacological effect, as well as the greater water-solubility, were described on the studies of the antipyretics and the analgesics. In this report, in order to investigate the pharmacological action of the urea-type derivatives as a related compound, with a comparatively low toxicity, the N-substituted amino acids urea derivatives of antipyrine and aryl compounds were synthesized. In this synthetic process of acylation of 1-methyl-1-phenylurea, an unusual reaction was observed and the structure of the products, as well as the productive procedure was studied.