YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
チオクト酸およびその関連化合物の合成研究 (第10報)
チオクト酸誘導体とビタミンB1との結合化合物の合成 その2
出口 義雄中西 和夫
著者情報
ジャーナル フリー

1963 年 83 巻 7 号 p. 704-707

詳細
抄録

Following the previous work*1 on the disulfide conjugate (I) of thioctic acid and thiamine, whose thiamine did not transit into blood cells, attempt was made to obtain compounds (IIa and IIb), in which the sulfur atom at 6- or 8-position of thioctic acid was bonded in disulfide form to thiamine and the other sulfur was in a dimer form. Methyl 8-chloro-6-hydroxyoctanoate (III), which was easily available, was converted into methyl 8-mercapto-6-bromo-octanoate (VIa) and from it, methyl 8, 8′-dithiobis[6-{2-{N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamido}-1-(2-hydroxyethyl)propenyl-dithio}öctanoate] (IIa) was obtained. Although transition of thiamine into blood cells was observed in II, its thioctic acid activity was abnormally low.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top