チオクト酸およびその関連化合物の合成研究 (第12報)
6-アシルチオ-8-クロロオクタン酸エステルの新合成法
1963 年 83 巻 7 号 p. 713-717
詳細
1963 年 83 巻 7 号 p. 713-717
It had been found that derivatives of haloöctanoic acid in 6- and 8-positions differed in their behavior towards sodium thiosulfate and that the use of 8-substituted derivative would be more desirable. In the present series of work, methyl 8-chloro-6-hydroxy-octanoate was derived to methyl 8-chloro-6-tosyloxyoctanoate (VII) by the action of tosyl chloride and methyl 6-acetylthio-8-chioroöctanoate (Va) was finally synthesized in a high yield of 73% by the application of thioacetic acid and calcium hydroxide in acetone.
