YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
結核菌に対する化学療法剤の研究 (第15報)
4-Thienyl-3-buten-2-one誘導体の合成ならびに抗菌作用について
藤川 福二郎平井 邦夫沢田 乙吉後藤 淳子内藤 益一津久間 俊次
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1963 年 83 巻 7 号 p. 728-731

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Nineteen kinds of 4-thienyl-3-buten-2-one derivatives were synthesized and their antibacterial activity was examined with a sensitive strain of human-type tubercle bacilli H37Rv and a strain resistant to INH, PAS, and streptomycin. Thiosemicarbazone, 4-methyl-, 4-ethyl, and 4-allyl-thiosemicarbazones of 4-thienyl-3-buten-2-one showed antibacterial activity against both sensitive and resistant strains at 6.25γ/ml. and salicyloylhydrazone at 12.5γ/ml., while 4-propyyl-, 4-butyl-, 4-(p-tolyl)-, 4-(o-methoxyphenyl)-, 4-(p-methoxyphenyl)-thiosemicarbazones, p-hydroxybenzoylhydrazone, p-aminobenzoylhydrazone, phenylhydrazone, and p-nitrophenylhydrazone at 25γ/ml.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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