YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
サルファ剤のN-グルクロナイドの研究 (第8報)
ラッテ肝ホモジネート中スルファピリジン-N4グルクロナイドの生成について
扇谷 正三郎橋本 一夫片岡 秀雄門田 明子
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1963 年 83 巻 9 号 p. 875-881

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A new method was found for the estimation of N4-glucuronides of sulfapyridine in the reaction mixture of sulfapyridine with the rat liver homogenate. The mechanisms of the N4-glucuronide formation in vitro from sulfapyridine and the boiled extract of the liver (UDPGA) was examined with rat liver homogenate, it was concluded that self apyridine N4-glucosiduronate was not formed by the action of the liver enzyme in vitro, but was formed non-enzymatically.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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