YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
知母のサポニンについて (第1報)
川崎 敏男山内 辰郎板倉 宣子
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1963 年 83 巻 9 号 p. 892-896

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1. The fresh rhizomes of Anemarrhena asphodeloides BUNGE collected in July were found to contain sarsasapogenin and markogenin, as previously reported by Takeda, et al., and also one more sapogenin, neogitogenin (m.p. 253-254°, [α]D19-66.4° (c=0.24, CHCl3); diacetate, m.p. 215-219°, [α]D18-112° (c=0.41, CHCl3)).
2) A commercial crude drung“Timo” (the dried and stored rhizomes of A. asphodeloides BGE.) contained sarsasapogenin, and six steroid saponins were detected in its methanol extract. They were respectively named timosaponin A-I, A-II, A-III, A-IV, B-I, and B-II. A-III was isolated as colorless prisms, m.p. 317-322° (decomp.), [α]D27-41.6° (c=0.27, dioxane) and B-I as amorphous powder, m.p. 170-180°.
3. Timosaponin A-III was composed of sarsasapogenin, D-glucose, and D-galactose, and the sugar moiety was presumed to be a biosc. B-I and A-I were regarded, respectively, as a parent saponin having another mole of glucose, and the prosapogenin, of A-III.

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