YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
オロチン酸の製剤学的研究 (第6報)
オロチン酸-アミン反応体の理化学的性質
中谷 弘実西川 正夫水田 栄治
著者情報
ジャーナル フリー

1964 年 84 巻 11 号 p. 1051-1056

詳細
抄録

Physicochemical properties of orotic acid-amine reaction products were examined, and their structure and state in aqueous solution were observed.
Since the infrared spectrum of the reaction product exhibited absorptions for carboxyl and amine ions, the product was considered to have a structure in which the amine is bonded to the carboxyl group in orotic acid in an ammonium salt type.
Freezing-point depression of the aqueous solution of the reaction product was measured and the reaction product was found to be present in the solution dissociated into orotic acid and ammonium ions.
Thermal examination of the aqueous solution system of orotic acid and amines showed that the heat of mixing of orotic acid and amine is equal to the sum of heat of ionization of each component, and this fact endorses the presumed ionic dissociation of the salt.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top