YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
平滑筋における薬物受容体の研究 (第9報)
血管平滑筋におけるAgonist感受性に関する研究
岩城 利一郎加田 実宮沢 英雄
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ジャーナル フリー

1964 年 84 巻 11 号 p. 1091-1093

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With the following four specimen of tissue portions of blood-vessel from extract of rabbit, pulmonary artery, arcus areae and upper part, lower part of aorta descendens, according to the Magnus method with adrenaline, barium chloride, histamine, serotonin and ACh, the contraction effect was studied from the value of relative activity in the maximum contractive reaction, and its 50% contractive concentration and the slope were obtained, by preparing each dosage-activity curve.
The results obtained were:
1) adrenaline showed the strongest effect upon the contraction mechanism of smooth muscle of rabbit blood-vessel, and both serotonine and histamine followed adrenaline.
2) the contraction effect of ACh against blood-vessel was found to be very weak.
3) the contraction effect of barium chloride was found to be strong, however, it needed high concentration.
4) the slope ratio of dosage-activity curve was: 0.7 (aorta descendens)-1.1 (pulmonary artery) with adrenaline, 1.5 with barium chloride, 1.1 with histamine, 0.9 (aorta descendens)-1.1 (pulmonary artery) with serotonine and 1.0 with ACh.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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