Abstract
A growth inhibitory test of the organo-mercuric compounds, containing theophylline derivatives against eight sorts of strains, such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Alcalescens Dispar type I, Psuedomonas aeruginosa, Salmonella paratyphi B, Proteus OX 19 and Trichophyton mentagrophytes was studied by the paper disk method with thimerosal and phenylmercuric acetate as controls, and any derivatives was found to be inferior to thimerosal in its antibacterial activity. However, it was found that 7-(phenylmercuri) theophylline (1), 7-(p-tolylmercuri) theophylline (2), o-(chloromercuri) phenol (12) and (o-bromomercuriphenyl) methanol (17) showed similar antibacterial properties to phenylmercuric acetate. Among the eight sorts of bacterial strains, gram negative bacteria had an tendency to be less sensible than gram positive bacteria against organo-mercuric compounds.
