YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
抗ガン剤に関する研究 (第11報)
種々のカルビノールおよびフェノール類のメタンスルホネートの合成ならびにその生物学的活性
亀谷 哲治梅沢 修関根 清子織田 健石黒 正子水野 伝一
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1964 年 84 巻 3 号 p. 237-246

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There have been numerous reports on Myleran among various alkyl methanesulfonates and 39 kinds of various derivatives of carbinols were synthesized to examine their antibacterial, antifungal, and antitumor actions. A large number of methanesulfonates of various phenolic compounds were synthesized and their antitumor action was examined. Among these compounds, 2-chloro-3′, 4′-dimethoxyacetophene was found to have considerable effect against Ehrlich ascites tumor.
Reaction of pyrocatechol with chloroacetyl chloride and chloropropionyl chloride was also examined.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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