キナルジン, レピジンおよびそれらのN-オキサイドとアミルニトリトの反応

抄録

Quinaldine 1-oxide reacts with amyl nitrite in liquid ammonia, in the presence of metal amide, and produces quinaldaldehyde 1-oxide oxime (II) in 27-51% yield, with by-product formation of quinaldonitrile 1-oxide (III), quinaldamide 1-oxide (IV), qninaldonitrile (V), and quinaldamide.
The same reaction of lepidine 1-oxide resulted in the difficulty of separating the product but formation of cinchoninaldehyde 1-oxide oxime was proved by its isolation.
Quinaldine and lepidine both easily afforded the corresponding quinolinecarboxaldehyde oxime in a good yield of 55-67%.