YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
2-Piperidinomethyl-1-tetralone類似化合物の合成とその中枢抑制作用
堀井 善一森川 浩一田村 恭光人見 正博
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1964 年 84 巻 5 号 p. 395-399

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A number of piperidinoalkyl derivatives were prepared and their acute toxicity, potentiation of methylhexabital narcosis, and protection against electroshock convulsion were examined to clarify the relationship between chemical structure and central nervous system deppressant effect of 2-piperidinomethyl-1-tetralone analogs. Among the compounds tested, 2-piperidinomethyl-3-methyl-1-tetralone (III) possessed an activity comparable to that of 2-piperidinomethyl-1-tetralone (I), but others had lesser activities.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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