YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Thiamineの高分子誘導体の研究 (第2報)
Disulfide型高分子誘導体
伊田 忠夫野田 和夫高橋 省二内海 勇
著者情報
ジャーナル フリー

1964 年 84 巻 5 号 p. 426-431

詳細
抄録

High-molecular derivatives of thiamine with disulfide-linkage were prepared by the thiol-disulfide exchange reaction between thiamine disulfide and homopolymers of N-acryloylcysteine, N-methacryloylcysteine or copolymers of other vinyl compounds. Examinations were made on the same reaction with other polyvinylthiols and starch dimercaptoallyl ethers but the objective disulfide compounds were not obtained.
Stability of these disulfide-type high-molecular thiamine derivatives was examined by mixing with sodium hydrogen carbonate-starch (1:1) and calcium carbonate and it was found that they were markedly more stable than thiamine hydrochloride and were very stable when suspended in buffer solutions of various pH and heated.
Determination of thiamine excreted in human urine after their oral administration showed that the amount was equal to or greater than that of thiamine hydrochloride, both in the case of homopolymers and copolymers. Urinary excretion was almost doubled in the poly (N-acryloylcysteine) derivative. Urinary excretion extended over a long period, showing the specific action of the polymer derivatives.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top