YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
抗白癬菌剤の研究 (第1報)
Tetrahydro-2H-1,3,5-thiadiazine-2-thioneの誘導体の合成ならびに抗白癬菌作用
田久保 敬男唯岡 知徳
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1964 年 84 巻 5 号 p. 466-469

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Condensation of ammonium phenyldithiocarbamate with aliphatic amine hydrochloride in ethanol and cyclization of the product by dropwise addition of 37% formaldehyde under stirring afforded 10 kinds of 2-thio-1, 3, 5-tetrahydrothiadiazine derivatives. In vitro biological tests of these compounds showed that they had only a weak antibacterial activity but some of them had a strong antifungal activity.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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