摘出鶏胎心における強心配糖体の作用に影響をおよぼす因子について (第1報)
強心配糖体の作用におよぼす血清およびCortisolの影響
1964 年 84 巻 7 号 p. 596-601
詳細
1964 年 84 巻 7 号 p. 596-601
Effect of serum, serum albumin, and cortisol in suppressing the action of cardiotonic glycosides was examined with isolated embryonic chick heart.
1) Action of digitoxin, digoxin, and g-strophanthin on isolated embryonic heart was markedly suppressed by the addition of serum but this suppressive effect was weaker in serum from adrenalectomized rat than normal serum. Addition of cortisol to the serum of adrenalectomized rat made the suppressive effect approximately equal to that of normal serum.
2) Toxicity of these cardiotonic glycosides in the Locke solution containing cortisol was clearly weaker than that in the Locke solution. This toxicity in the Locke solution containing cortisol and albumin was almost the same as that in normal serum.
These evidences indicate antagonism of cortisol against the action of cardiotonic glycosides in isolated embryonic chick heart.
