YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ニトロフラン系化合物の薬学的研究 (第13報)
4-Alkyl-5-(5-nitro-2-furyl)-2,4-pentadienoic Acid誘導体の合成ならびに構造活性相関について
才川 勇鈴木 保之
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1964 年 84 巻 7 号 p. 646-651

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4-Alkyl-5-(5-nitro-2-furyl)-2, 4-pentadienoic acids (II) were prepared by the reaction of ketene with α-alkyl-5-nitro-2-furanacroleins (I) in the presence of an appropriate catalyst such as boron trifluoride followed by acid treatment of the intermediate β-lactone.
Amides (IV) of II shown in Table I were obtained by the known method. Antibacterial and antifungal activity against five kinds of microörganisms is summarized in Table II.

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