1964 年 84 巻 8 号 p. 744-751
Methods were examined for the syntheses of 1-acetylpiperazine (IV) and 1-[(2-methoxy-4-propylphenoxy)acetyl]piperazine hydrobromide (X), the intermediate for obataining asymmetric 1, 4-disubstituted piperazine derivatives which are interesting as antipyreticanalgesic. Compounds XI to XIII were obtained. Over 20 kinds of 1, 4-bis(aryloxyacetyl)piperazine derivatives were obtained by the reaction of 1, 4-bis(haloacetyl)piperazine and phenols, as shown in Table II.