Azabenzomorphan関連化合物の合成研究 (第5報)
4-Bromomethylcarbostyrilのニトリル化反応と4-置換-carbostyril誘導体の合成
1965 年 85 巻 10 号 p. 867-870
詳細
1965 年 85 巻 10 号 p. 867-870
In order to obtain the starting material (III) for the synthesis of the compound (IV), a kind of compounds related to azabenzomorphan, various kinds of 4-substituted quinoline derivatives were synthesized. At the same time, nitrilation of 4-bromomethylcarbostyril (IX) was examined. Attempts to prepare X by nitrilation of IX unexpectedly afforded the dimeric type XI, whose structure was proved by its chlorination and reduction.
In order to obtain II by decarboxylation of the amino acid (I), IX was condensed with diethyl acetamidomalonate and XXI thereby formed was hydrolyzed and submitted to decarboxylation to form the amino acid (I). However, decarboxylation of I was not effected.
