放射性ヨウ化馬尿酸ナトリウムの安定性

抄録

Stability of sodium o-iodohippurate [¹³¹I] in various formulae and storage conditions was studied. Protecting effect against self-radiation damage was found in benzyl alcohol, citric acid, and sodium o-iodohippurate itself, while addition of sodium chloride gave no effect on the stability of this compound. This radioactive compound seemed to be more stable in lower pH and more iodines were released by autoclaving. There was no significant effect of storage temperature but there was a marked effect of direct sunlight.
Several preliminary experiments were made to determine the reliability of paper chromatographic method for detecting radiochemical purity of this compound. Prevention of loss of radioactivity before measurement, exchange reaction during development, and comparison of the accuracies of scanning method, counting method, with well-type scintillation counter, and electrophoretic method were described.