YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
4,6-Dinitroquinoline 1-Oxideの抗ガン性
岡本 敏彦長谷川 陽一木下 忠俊石黒 正子水野 伝一
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1965 年 85 巻 8 号 p. 720-724

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4, 6-Dinitroquinoline 1-oxide was tested for antitumor activity using Ehrlich ascites carcinoma and S-180 in ascites as well as solid type.
The effect is remarkable in the case of ascites type, both for Ehrlich and S-180, showing 100% longevity in 30 days in a dose of 100γ/mouse/day (5mg./kg./day) for Ehrlich, 300γ/mouse/day (15mg./kg./day) for S-180. The chronic LD50 is 150mg./kg. for mice, and the chemotherapeutic index is 30. Toxicity for rats and dogs was also tested.
A synergestic effect was found when 4, 6-dinitroquinoline 1-oxide was given together with a sub-effective dose of Mitomycin-C and INAH to the solid type of Ehrlich ascites carcinoma (Table VI and Fig. 6).

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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