YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
酸アミド類の研究 (第3報)
10-(2-Alkylaminoacyl) phenothiazin
豊田 猛須山 正金尾 清造
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1965 年 85 巻 8 号 p. 739-743

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In the synthesis of 10α-alkylaminoacylphenothiazine, the aminoacyl groups used were R=N-CH2-CO-, CH3CH(N=R)-CO-, R=N-CH2-CH2-CO-, CH3-CH2-CH(N=R)-CO-, (CH3)2-CH-CH2-CH(N=R)-CO-, and C6H5-CH2-CH(N=R)-CO-, and the amines used for them were dimethyl-, diethyl-, isopentyl-, and β-phenethyl-amines, tyramine, piperidine, piperatine, and morpholine. Application of morpholine to 10-(2-bromisovaleryl) phenothiazide failed to give the aminated product but gave 10-(dimethylacryl) phenothiazine, m.p. 158-159°, probably due to steric hindrance. Application of ethanolamine to 10-(chloracetyl) phenothiazine resulted in its decomposition into N, N-bis (2-hydroxyethyl) glycine, m.p. 195°, and phenothiazine.

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