YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ビリダジン誘導体(第9報) : 2,3-ジアザフェノチアジン誘導体の合成
米田 文郎大高 孝之新田 義博
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1966 年 86 巻 10 号 p. 887-890

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Treatment of 5-(o-aminophenylthio)-4-chloro-3(2H)-pyridazinone (I) with hydrochloric acid results in rearrangement-cyclization to produce 10H-benzo[b]pyridazino[4, 5-e]-(1, 4)-thiazine-4(3H)-one (II), but 5-(o-aminophenylthio)-4-chloro-2-methyl-3(2H)-pyridazinone (IV) does not undergo rearrangement by treatment with hydrochloric acid. Treatment of IV with potassium carbonate in dimethylformamide results in direct cyclization to produce 2-methyl-10H-benzo[b]pyridazino[4, 5-e]-(1, 4)-thiazin-1(2H)-one (V). Derivatives of II substituted in 3-position with various groups were synthesized.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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