YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
dl-7,4'-O, O-Dibenzyl-3′-bromo-N-methylcoclaurineの合成とその光学分割 : 複素環式化合物の合成研究 第153報
亀谷 哲治高野 誠一増子 和子
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1966 年 86 巻 10 号 p. 976-979

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One of the important starting materials for biscoclaurine-type alkaloids, dl-3'-bromo-7, 4'-O, O-dibenzyl-N-methylcoclaurine (III) was synthesized through its amide (VIII), 3, 4-dihydroisoquinoline (IX), and the methiodide (X). Optical resolution of III using di- p-toluoyl-d-tartaric acid gave the levorotatory III. The dextrorotatory III was obtained from the free base recovered from the mother liquor by treatment with l-tartaric acid.

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