1966 年 86 巻 5 号 p. 356-366
Coloration of solid pharmaceutics was assumed to proceed through the formation of a kind of solution system by the water of hydration contained in the pharmaceutics and examinations were made to see if reaction kinetics in dilute solution could be applied in this case. It was thereby found that coloring rate was proportional to the rate of hydration in simple powders, and a linear relation was found to hold between coloring rate constants and the reciprocal of absolute temperature. If conditions were selected, periodical change of such coloration could be predicted as in the case of dilute solutions. On the bases of these ideas, examinations were made also on granules and tablets, and comparison of the values calculated from the result of acceleration tests and those obtained on actual samples by standing for some period at room temperature showed fairly good agreement.