ジブカイン塩基の物理化学的性質および作用性に及ぼす対イオンの影響に関する研究(第3報) : 蛙坐骨神経の興奮伝導遮断作用と親媒性に及ぼす影響

抄録

Effects of counter ions on the onset time, effective duration, and half-blocking concentration of dibucaine base were evaluated by the method described previously. They were also reviewed in reference to the ratio and rate of distribution between chloroform and water, the rate of permeation through the cellophane membrane, and the rate of diffusion in water were additionally pursued. A certain relationship was found between the ratio of distribution and half-blocking concentration, as was the case between the rate of distribution and onset time or effective duration.