ジブカイン塩基の物理化学的性質および作用性に及ぼす対イオンの影響に関する研究(第4報) : ジブカイン塩基の蛋白結合に及ぼす影響
1966 年 86 巻 9 号 p. 846-849
詳細
1966 年 86 巻 9 号 p. 846-849
Effects of counter ions on the interaction of dibucaine base and bovine serum albumin were investigated in reference to relations between anesthetic action and thermodynamic properties on protein binding. It seemed that entropy change of the interaction of dibucaine base and albumin was responsible for effective duration and half-blocking concentration of dibucaine base, determined on frog sciatic nerve fibers.
