薬剤の安定性に関する研究(第18報) : べンゾサイアダイアジン系化合物の安定性その9 : クロロサイアザイドのアルカリ水溶液中における逐次分解反応の中間体生成の最適条件について
1967 年 87 巻 12 号 p. 1447-1450
詳細
1967 年 87 巻 12 号 p. 1447-1450
The present investigation was undertaken to obtain, not using trial-and-error method but a mathematical one, the optimum for the production of the intermediate in the degradation of chlorothiazide (I). I decomposes to 4-amino-6-chloro-m-benzenedisulfonamide (IV) via consecutive reversible reactions, leading to the formation of N-(2-amino-4-chloro-5-sulfa-moylphenylsulfonyl) formamide (II) in aqueous alkali : [numerical formula]. II has a maximum concentration [II]max at [t]max, and [II]max was affected by the variation of pH. The [II]max had the maximum value of 65% of[I]0 at pH 7.6 by the calculation based on : k1=1.2×10-2min-1, k2=6.5×10-3min-1, and k3=2.0×10-4min-1.
