X線回折法による製剤の定量分析(第7報) : 内部標準法による懸濁液剤の定量

抄録

Quantitative determination by X-ray diffraction method, using calcium carbonate as the internal standard, was carried out on a suspension for internal use having as the main component acetylsulfisoxazole, sulfadimethoxin, acetylsulfisomezole, or O-benzoylthiamine disulfide, and suspension for injection having as the main component acetylhydrocortisone, in which calcium carbonate was added to each suspension, the mixture centrifuged, and the precipitate fixed in the holder. Acetylsulfisoxazole, sulfadimethoxin, and acetylhydrocortisone were determined by a precision comparable to the chemical method but acetylsulfisomezole gave a large error due to the tendency for its crystals to undergo preferred orientation. It was also found that the crystalline particles of O-benzoylthiamine disulfide were very small and the particle surface had been given a special processing so that centrifugation required time and complicated handling.