筋弛緩薬およびその拮抗薬の研究(第7報) : Hexylguanidineの筋弛緩の作用様式の解明補遺

抄録

Effect of hexylguanidine sulfate on rat diaphragm and intradermal weal test in guinea pig was examined, and following results were obtained. In rat diaphragm, it seemed that hexylguanidine acted on the neuromuscular junction and muscle. Antagonism between hexylguanidine and potassium ion, neostigmine, tetraethylammonium, d-tubocurarine and decamethonium was tested and it was found that hexylguanidine was not antagonized by them. Effect of hexylguanidine on rat diaphragm was different from that on sciatic-sartorius of frog in site and mode of action previously reported. The concentration of hexylguanidine required to block nerve-muscle preparation was higher in rat diaphragm than in frog sciatic-sartorius, but such difference in effective concentration was not observed with d-tubocurarine, decamethonium and procaine. Hexylguanidine had local anesthetic action as potent as procaine, and its action was more lasting than that of procaine in intradermal weal test of guinea pig.