Azaquinolizine類の合成研究(第1報) : 2,3,4,4a, 5,6,7,8-Octahydro-1H-pyrido[1,2-c]-pyrimidine誘導体の新合成法
1967 年 87 巻 6 号 p. 663-667
詳細
1967 年 87 巻 6 号 p. 663-667
2-(2-Aminoethyl) pyridine (XII), obtaind by the reduction of 2-(cyanomethyl) pyridine (XI) over Raney nickel catalyst at 80° at a high preasure, was derived to an urethan (XIV) by ethyl chlorocarbonate. The urethan was hydrogenated over Raney nickel catalyst at 130° at a high pressure, followed by ring closure to 2, 3, 4, 4a, 5, 6, 7, 8-octahydro-1H-pyrido [1, 2-c]-pyrimidin-1-one (IV), which was reduced with lithium aluminium hydride to 2, 3, 4, 4a, 5, 6, 7, 8-octahydro-1H-pyrido [1, 2, -c] pyrimidine (I). I and its 4-substituted derivatives (Ia∼I) were also obtained from the corresponding aldehydes and 2-(β-aminoethyl) piperidine.
