1967 年 87 巻 8 号 p. 915-922
The antitussive activity and site of action of α-(dimethylaminoethoxy)-ο-chlorobenzhydrol hydrochloride (clophedianol) have been investigated. The 50% antitussive doses (AtD50) of Clophedianol, administered intravenously, evaluated by the "coughing dog and cat" methods, were 16.4 (13.5∼19.9) mg./kg. in unanesthetized dogs and 13.8 (11.4∼16.7) mg./kg. in pentobarbitalized cats. Compared with the AtD50 of codeine, the antitussive activity of the drug is 23% and 18% that of codeine in dogs and cats, respectively. The antitussive action of the drug is due to selective depression of the cough center per se. This conclusion was derived from the following results. 1) When the durg was administered to various routes directing to the brain stem, much smaller doses were sufficient to obtain the same degree of effect as that by intravenous injection. 2) The drug showed neither effects on the sensory receptor in the tracheal mucosa nor those on the pulmonary stretch receptor. 3) The effect of the drug was not influenced by decerebration at the mid-collicular level. 4) The AtD50 of the drug depressed the centrally-induced cough while it showed no effect on the excitability of the reipiratory center. 5) The drug showed neither effect on the efferent respiratory pathways extending from the cervical cord to respiratory muscles, nor that on the bronchial muscles.