薬物の併用に関する研究(第3報) : アニリン系薬物の代謝におよぼす4-オキシアンチピリンおよびp-ヒドロキシアセトアニリドの影響について

抄録

Effect of the combined use of 4-hydroxyantipyrine and p-hydroxyacetanilide with acetophenetidine, acetanilide, and N-(p-ethoxyphenyl)-β-hydroxybutyramide on the metabolism of these agents was examined by measuring the metabloic rate of these principal agents using rat and rabbit liver specimens, and the blood level in rabbits. 1) p-Hydroxyacetanilide hardly affects the metabolism of the principal agents by liver slices but 4-hydroxyantipyrine inhibits their metabolism. 2) Blood level of these principal agents in rabbit is maintained by the combined use of 4-hydroxyantipyrine but is hardly affected by p-hydroxyacetanilide. These results indicate that both 4-hydroxyantipyrine and p-hydroxyacetanilide inhibit, though weakly, the metabolism of these principal agents and this effect is much higher in 4-hydroxyantipyrine.